Integrating the genotype and phenotype in hominid paleontology

Integrating the genotype and phenotype in hominid paleontology.

Competing interpretations of human origins and evolution have recently proliferated despite the accelerated pace of fossil discovery. These controversies parallel those involving other vertebrate families and result from the difficulty of studying evolution among closely related species. Recent advances in developmental and quantitative genetics show that some conventions routinely used by homi...

New Developments in Hominid Paleontology in South and East Africa

Recent years have witnessed remarkable progress in the unraveling of hominid evolution. The main advances registered--and which are now crying out for provisional synthesis--may be grouped under the following broad rubrics: (a) The discovery of further hominid fossils in East Africa [Omo, East Rudolf,. Chesowanja (27) and Olduvai] and in South Africa (Sterkfontein and Swartkrans) and their demo...

Genotype and phenotype of COVID-19: Their roles in pathogenesis

COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence th...

Chromosome Duplication (14q) and The Genotype Phenotype Correlation

Genotype–Phenotype Correlations in Iranian Myotonic Dystrophy Type I Patients

Objectives: Myotonic Dystrophy type I (DM1) is a dominantly inherited disorder with a multisystemic pattern affecting skeletal muscle, heart, eye, endocrine and central nervous system. DM1 is associated with the expansion and instability of CTG repeat in the 3chr('39') untranslated region of the myotonic dystrophy protein kinase (DMPK) gene located on chromosome 19q13.3. The aim of this study w...